Foot-and-mouth disease virus: stability of neutralizing antibody after freeze-drying and air-drying.

Freeze-drying of foot and mouth disease virus and its application in inactivated virus vaccine production

Five different subtypes of foot and mouth disease (FMD) virus propagated in BHK21 C13 monolayer cell cultures, namely 05, A5/!0, A22, C¡ and Asia 1/1, were used to study the stability of live virus during freeze-drying and subsequent storage. Binary ethyleneimine-inactivated FMD virus vaccines adjuvanted with purified saponin, "Quil-A", without aluminium hydroxide gel, were examined before and ...

Lyophilizing Foot-and Mouth Disease Virus at Low Drying Temperature

Assessment of Serum Neutralizing Antibody Titers against Foot-and-Mouth Disease Virus A and O in Young Colostrum-Fed Dairy Calves

Freeze-drying of Foot-and-mouth Disease Virus and Storage Stability of the Infectivity of Dried Virus at 4 C.

Foot-and-mouth disease virus, type A, strain 119, propagated in cultures of calf kidney cells and in the tongue epithelium of cattle was used. The process of freeze-drying was conducted in two cycles on unit volumes of 4 ml in Pyrex ampoules, averaging 150 ampoules per run, and was studied separately from the problems of storage. Ampoules containing freeze-dried virus were flame-sealed for eith...

Neutralizing Antibody Response in Cattle Following Vaccination against Foot-and-Mouth Disease